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Eosinophilic inflammatory diseases of the respiratory system: New therapeutic options
Watch a panel of experts discuss how to identify and manage patients with inflammatory respiratory diseases, with a focus on severe eosinophilic asthma.
- Recognize the role of eosinophils and type 2 inflammation in respiratory disease
- Understand the diagnostic methods used to differentiate inflammatory diseases of the respiratory system
- Recall disease states that may benefit from therapies that target the complex interaction between eosinophils and their environment
Targeting IL-1β in NSCLC: What does the future hold?
Watch a panel of experts discuss immunotherapy for non-small cell lung cancer (NSCLC) and the possible future role of interleukin-1β (IL-1β) blockade.
- Discuss the use of checkpoint inhibitors as immunotherapy for NSCLC and recognize their limitations
- Recall the rationale for targeting IL-1β in cancer immunotherapy and the IL-1β-targeted agents currently in clinical development for solid tumours
- Describe the clinical trials and data for IL-1β-targeting agents in NSCLC and consider how they may be used in clinical practice if approved
Andrew Menzies-Gow, ATS 2021: Tezepelumab in Oral Corticosteroid-Dependent Patients with Severe Asthma
It was a pleasure to talk to Professor Andrew Menzies-Gow (Royal Brompton Hospital and Imperial College, London, UK) around his recent analysis of the NAVIGATOR data, investigating the effect of tezepelumab in OCS-dependent severe asthma patients (Clinical Trial Identifier: NCT03347279). The abstract ‘Effect of Tezepelumab in Oral Corticosteroid-Dependent Patients with Severe Asthma: Results From the […]
Sara Tomassetti, ATS 2021: Post-COVID-19 Interstitial Lung Syndrome
We were delighted to catch up with Dr Sara Tomassetti (Careggi University Hospital, Florence, Italy) around interstitial lung changes following SARS-CoV-2 infection. The abstract ‘A Multidisciplinary Multicenter Study Evaluating Risk Factors, Prevalence and Characteristics of Post-COVID-19 Interstitial Lung Syndrome PCOILS.‘ (ABSTRACT NUMBER: A1748) was presented at ATS 2021 International Conference, 14-19 May, 2021. Questions What […]
Dr. Ian Pavord and Dr. Simon Couillard, ATS 2021: The OxfoRd Asthma attaCk risk ScaLE (ORACLE)
We had the great pleasure to meet with Dr. Ian Pavord (University of Oxford, Oxford, UK) and Dr. Simon Couillard (University of Oxford, Oxford, UK and University of Sherbrooke, Sherbrooke, Canada) to learn about the OxfoRd Asthma attaCk risk ScaLE (ORACLE), a proof-of-concept scale to predict asthma attacks. You can view the prototype Oxford Asthma […]
Sarah Diver, ATS 2021: The CASCADE Study
TouchRESPIRATORY got the opportunity to catch up with Dr Sarah Diver (University of Leicester, Leicester, UK) around the CASCADE study, investigating the use of tezepelumab in patients with moderate-to-severe uncontrolled asthma. ‘Effect of tezepelumab on airway inflammatory cells, remodeling and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma: a randomized, double-blind, placebo-controlled trial’ was presented at […]
Dupilumab—A Potential New Biologic for Chronic Rhinosinusitis with Nasal Polyps
US Respiratory & Pulmonary Diseases. 2020;5(1):15-7 DOI: https://doi.org/10.17925/USPRD.2020.5.1.15
Chronic rhinosinusitis (CRS) is a clinical syndrome defined by symptomatic inflammation of the paranasal sinuses and nasal cavity for at least 12 weeks in duration. Historically, CRS has been classified into 2 subgroups, CRS with nasal polyps (CRSwNP) and CRS without nasal polyps. Those with CRSwNP have a more significant burden of disease and poor […]
Nintedanib—A Potential New Therapy for Systemic Sclerosis-associated Interstitial Lung Disease
US Respiratory and Pulmonary Diseases. 2020;5(1):28-32 DOI: https://doi.org/10.17925/USPRD.2020.5.1.28
Systemic sclerosis (SSc) is an autoimmune disorder characterized by inflammation and fibrosis of the skin and other organs. It has a range of clinical manifestations, and the typical internal organs involved include the lungs, kidneys, heart, and gastrointestinal tract. Though it is an uncommon condition, the mortality rate of this disease is higher than any […]
Evidence and E-cigarettes – The English Perspective
European Respiratory & Pulmonary Diseases. 2019;5(1):10–11
Recently, there has been much media coverage on the topic of e-cigarettes. Approaches to new data suggesting that e-cigarettes may be harmful have differed between countries. In particular, the attitude of public health bodies in England has differed significantly from those in other countries internationally. American electronic cigarette company Juul has been accused of deliberately […]
Elexacaftor-tezacaftor-ivacaftor—A Combination Therapy for Phe508del Cystic Fibrosis
US Respiratory & Pulmonary Diseases. 2019;4(1):15–9
Cystic fibrosis (CF), an inherited disease affecting all races and ethnicities, results from defects in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which leads to dysregulations in the ion and fluid balance across epithelial membranes throughout the body.1–3 The CFTR protein is an anion channel that functions as a transmembrane traffic ATPase which is […]