This analysis of COVIDENCE UK investigated potential sociodemographic, behavioural, clinical, pharmacological and nutritional determinants of antibody responses to administration of SARS-CoV-2 vaccination and booster doses. It was a pleasure to talk with Professor Adrian Martineau (Queen Mary University of London, London, UK) around the aims, methodology and patient population of the COVIDENCE UK study and […]

BLU-5937 is a highly selective P2X3 antagonist currently being investigated for the treatment of chronic cough. touchRESPIRATORY were delighted to speak with Professor Alyn Morice (Hull York Medical School, University of Hull, Castle Hill Hospital, Yorkshire, UK) around the challenges and unmet needs in the treatment of refractory chronic cough and the aims, design and […]

The TETON programme consisted of two replicate, 52-week, randomised, double-blind, placebo-controlled, phase 3 studies, investigating inhaled treprostinil in the treatment of idiopathic pulmonary fibrosis (NCT04708782, NCT05255991). touchRESPIRATORY were delighted to talk with Dr. Steven D. Nathan (Inova Fairfax Hospital, Annandale, VA, USA) to discuss the aims, design, eligibility criteria and endpoints being investigated in the TETON […]

INVENT COVID was a phase II study, which investigated the efficacy and safety of intravenous imatinib in acute respiratory distress syndrome induced by COVID-19 (Clinical Trials Identifier: NCT04794088). touchRESPIRATORY were delighted to speak with Dr. Leila Atmowihardjo (Amsterdam Medical Centers: Academic Medical Center, Amsterdam, The Netherlands) to discuss the aims, design, eligibility criteria and findings […]

Paediatric sleep-disordered breathing (SDB) refers to a spectrum of respiratory disorders with intermittent upper-airway obstruction and sleep disruption in children.1 SDB spans primary snoring, upper-airway resistance syndrome, obstructive hypoventilation and obstructive sleep apnoea (OSA), listed in order of increasing severity of SDB stratified by polysomnography.2 Paediatric OSA is characterized by recurring episodes of airway obstruction, which […]

With the advent of newer drugs targeting the biochemical pathways that lead to cough, it is increasingly important to understand the definition, pathogenesis and management of this symptom. Several specialist bodies also recognize the need for guidance in this area, and the American College of Chest Physicians (ACCP) and European Respiratory Society (ERS) have both […]

Coronavirus is a family of enveloped RNA viruses that include the original SARS coronavirus (SARS-CoV) and the recently emerged SARS-CoV-2. According to the World Health Organization, there have been over 500 million confirmed SARS-CoV-2 infections, and well over 6 million deaths from coronavirus disease 2019 (COVID-19).1 Although the recovery rate from COVID-19 is estimated to be […]

Asthma affects around 339 million people worldwide,1 with approximately 10% of these experiencing severe disease.2 Despite many advances in asthma therapy in recent years, including the advent of biologic therapies, many patients with severe asthma cannot control their symptoms.2,3 Severe, uncontrolled asthma is extremely debilitating and involves frequent exacerbations, significant limitations on lung function and a reduced quality […]