The TETON programme consisted of two replicate, 52-week, randomised, double-blind, placebo-controlled, phase 3 studies, investigating inhaled treprostinil in the treatment of idiopathic pulmonary fibrosis (NCT04708782, NCT05255991). touchRESPIRATORY were delighted to talk with Dr. Steven D. Nathan (Inova Fairfax Hospital, Annandale, VA, USA) to discuss the aims, design, eligibility criteria and endpoints being investigated in the TETON […]

The InPedILD trial was a phase 3, double-blind placebo-controlled trial investigating nintedanib in children and adolescents with fibrosing interstitial lung diseases (ClinicalTrials.gov: NCT04093024). We were delighted to speak to Dr. Robin Deterding (University of Colorado; Children’s Hospital Colorado, Aurora, CO, USA) to discuss the aims, design, eligibility criteria and findings from the phase 3 study. […]

Herpes Zoster (HZ) infection is a vaccine-preventable disease that occurs when a previous infection with varicella-zoster virus (VZV) is reactivated; patients with chronic obstructive pulmonary disease (COPD) and asthma have suppressed immunity and therefore are at a higher risk of being infected and experiencing complications. We caught up with Dr. Barbara Yawn (University of Minnesota, […]

Once-nightly sodium oxybate (FT218) is currently being investigated in the open label phase 3 study RESTORE (NCT04451668) for the treatment of narcolepsy. We caught up with Prof. John Harsh (University of Colorado Boulder, Boulder, CO, USA) to discuss the aims, design, inclusion criteria and interim findings of the RESTORE study. The abstract ‘LONG-TERM SAFETY OF […]

With the advent of newer drugs targeting the biochemical pathways that lead to cough, it is increasingly important to understand the definition, pathogenesis and management of this symptom. Several specialist bodies also recognize the need for guidance in this area, and the American College of Chest Physicians (ACCP) and European Respiratory Society (ERS) have both […]

Asthma affects around 339 million people worldwide,1 with approximately 10% of these experiencing severe disease.2 Despite many advances in asthma therapy in recent years, including the advent of biologic therapies, many patients with severe asthma cannot control their symptoms.2,3 Severe, uncontrolled asthma is extremely debilitating and involves frequent exacerbations, significant limitations on lung function and a reduced quality […]

Asthma is a common and heterogeneous disease affecting approximately 10% of the population.1 Severe asthma – a subset of the disease that affects a fraction of patients with asthma but comprises more than half of the morbidity, mortality and costs relating to asthma – is predominantly caused by smouldering type-2 eosinophilic airway inflammation.2,3 Until now, the main strategy […]

Lung cancer remains the leading cause of cancer-related death.1 However, five-year survival in lung cancer varies greatly based on the stage of the disease at diagnosis.2 Early lung cancer diagnosis through screening with low-dose computed tomography (CT) demonstrated a 20% reduction in lung cancer mortality in current or former smokers with a history of 30 or more […]