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    An Introduction to Allergic Diseases

    The incidence of respiratory allergies is increasing, particularly in industrialized areas. Allergic inflammation can occur in both the upper and lower airways, and can differ substantially in intensity. Traditional drug therapy such as antihistamines, corticosteroids, anticholinergic agents and leukotriene inhibitors is important in reducing and preventing symptoms and is essential in acute use. More recent therapies including anti-immunoglobin E (IgE) therapy, anti-interleukin (IL) monoclonal antibodies, and phosphodiesterase 4/phospholipaseA2 inhibitors, have improved outcomes. However, in order to develop more effective therapies, further research is needed into the molecular mechanisms underlying respiratory allergy onset, particularly in terms of intracellular reactions and the cytosolic Ca2+ balance.

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