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The role of eosinophils in physiology and disease: Is complete depletion of eosinophils the goal?

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Airway Disease, Allergy, Asthma Watch Time: 34 mins

touchTALKS The role of eosinophils in physiology and disease: Is complete depletion of eosinophils the goal?

Watch Dr Enrico Heffler describe how eosinophilic inflammation can be targeted for the treatment of inflammatory respiratory diseases.

 
Video Chapters
The role of eosinophils in homeostasis and disease

Dr Enrico Heffler describes how eosinophils contribute to immune homeostasis, their involvement in the pathogenesis of inflammatory diseases and the central role played by interleukin-5 in their life cycle.

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Video Chapters
Immunobiology of eosinophilic therapy

Dr Enrico Heffler discusses the mode of action and approved therapeutic indications of biologic drugs targeting eosinophilic inflammation via inhibition of interleukin-5 or other molecular targets.

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Video Chapters
Pipeline therapies for eosinophilic immunologic disease

Dr Heffler discusses the evolving landscape of biologics targeting eosinophilic inflammation, covering both novel indications for approved agents and emerging drugs under clinical development.

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Overview & Learning Objectives
Overview

In this touchTALKS, Dr Enrico Heffler describes the rationale for targeting eosinophilic inflammatory pathways in respiratory inflammatory diseases and discusses the most recent advances in existing and emerging biological therapeutic agents.

Learning Objectives

After watching this activity, participants should be better able to:

  • Understand the dynamics of eosinophils across the human body in wellness and disease
  • Discuss clinical scenarios in which eosinophilic therapy may be beneficial
  • Recognize how new eosinophilic therapies offer promise for the future treatment of eosinophil-mediated diseases
Faculty & Disclosures
Dr Enrico Heffler

Humanitas University of Milan, Italy

Enrico Heffler is an Assistant Professor in Respiratory Diseases at Humanitas University of Milan, Italy. He specializes in allergy, clinical immunology, personalized medicine, asthma and allergy. read more

He received his MD in 2003 from the University of Torino, Italy; he specialized in Allergy and Clinical Immunology in 2008 and received a PhD in Experimental Medicine and Therapy (Experimental and Clinical Pharmacology) in 2014 from the University of Torino. Between 2015 and 2017, he was Assistant Professor in Respiratory Diseases at the University of Catania. His main research interests are airway and systemic inflammation, disease control and pathogenic mechanisms of asthma (mainly severe asthma), chronic rhinosinusitis with nasal polyps and anaphylaxis. His research interests also include the pathogenesis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), food allergies and epidemiological aspects of respiratory allergic diseases.

Dr Heffler discloses: advisory board and speaker fees from AstraZeneca, Circassia, GlaxoSmithKline, Nestlè Purina, Novartis, Sanofi-Genzyme, and Stallergenes-Greer.

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