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A 68-year-old woman with nodular bronchiectasis presents with persistent productive cough, intermittent regurgitation and recurrent ‘chest infections’ despite 12 months of once-daily proton pump inhibitor (PPI) therapy. Her clinician has doubled the PPI dose and is considering long-term azithromycin. Sputum has not been sent for mycobacterial culture in over a year. She has lost 3 kg, at times […]

Rebecca Bascom, ATS 2021: MN-001 in Idiopathic Pulmonary Fibrosis

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Published Online: Jun 16th 2021

We were delighted to talk with Dr Rebecca Bascom (Penn State Hershey Medical Center, Hershey, PA, US) around her study investigating the use of MN-001 in patients with idiopathic pulmonary fibrosis.

A Single-Center, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of MN-001 (Tipelukast) in Subjects with Idiopathic Pulmonary Fibrosis.‘ was presented at ATS 2021 International Conference, 14-19 May, 2021.

Questions

  1. Could you give us a brief overview of the challenges in treating idiopathic pulmonary fibrosis (IPF) and how therapy has evolved in recent years? (0:15)
  2. What is tipelukast and what is its mechanism of action? (0:50)
  3. What were the aims and design of the first clinical trial of tipelukast? (1:25)
  4. What were the efficacy and safety findings of the study after 12 months? (2:02)
  5. What will be the next steps for tipelukast in this indication? (2:39)

Disclosures: Rebecca Bascom has nothing to disclose in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Victoria Jones.

Filmed as a highlight of ATS 2021 (Virtual).

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