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A 68-year-old woman with nodular bronchiectasis presents with persistent productive cough, intermittent regurgitation and recurrent ‘chest infections’ despite 12 months of once-daily proton pump inhibitor (PPI) therapy. Her clinician has doubled the PPI dose and is considering long-term azithromycin. Sputum has not been sent for mycobacterial culture in over a year. She has lost 3 kg, at times […]

Michael Blaiss, AAAAI 2022: An Analysis of Gefapixant in Chronic Cough

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Published Online: Mar 14th 2022

touchRESPIRATORY caught up with Dr. Michael S. Blaiss (Medical College of Georgia, Augusta University, Augusta, GA, USA) to discuss his analysis of phase 3 trials of gefapixant in chronic cough.

The abstract ‘Comparisons Of Baseline Characteristics And Treatment Efficacy In Individuals With Refractory Or Unexplained Chronic Cough Enrolled In Phase 3 Trials Of Gefapixant‘ was presented at AAAAI 2022, 25-28 February.

Questions

  1. What have the COUGH-1 and COUGH-2 studies taught us about the efficacy and safety of gefapixant in patients with RCC or UCC? (0:20)
  2. What were the aims of the current comparison of baseline characteristics and treatment efficacy in patients in these two studies? (1:49)
  3. What questions remain unanswered? (3:22)

Disclosures: Michael Blaiss discloses consulting for Merck and Bellus, serving on advisory boards for Merck and Bellus, and participating in Speaker’s Bureaus for Merck.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.

Filmed in coverage of the AAAAI meeting 2022

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