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Kate Clair Cruden Hughes, Amy Hai Yan Chan

Asthma affects nearly 300 million people worldwide.1 Despite a notable decline in age-standardized prevalence, mortality and disability-adjusted life years over the past three decades, the burden of asthma remains high in many countries including low-middle-income countries.2 Climate change is also predicted to significantly impact asthma and other respiratory-related conditions, as rising global temperatures lead to longer pollen […]

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Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are the dominant cause of the worsening and high mortality of chronic obstructive pulmonary disease (COPD), and are associated with higher healthcare costs as part of COPD management. AECOPD is characterized by ...

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Lung cancer accounts for the highest cancer-related mortality and is the second most common cause of malignancy worldwide.1 Diagnosis at an early stage (ES) has a direct effect on management and survival rates. Overall, the 5-year survival rate from 2013 to 2019 ...

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Laurence Désy, Philippe Lachapelle, Simon Couillard

The topic of the carbon footprint of human activities is one frequently discussed worldwide. There have been conscious efforts across multiple fields, including healthcare, to reduce their carbon footprint. In Canada, 4.6% of greenhouse gases (GHG) are manufactured by the healthcare ...

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The natural progression of neuromuscular disease (NMD) inevitably involves respiratory system failure. Increasing respiratory muscle weakness causes worsening hypoventilation, leading to hypercapnia and, eventually, hypoxemia. The American College of Chest Physicians (CHEST) recently published guidelines on the respiratory management of ...

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Sleep disturbances are exceedingly common and potentially morbid in patients with neuromuscular diseases (NMD).1 A constellation of physiologic changes occur in patients with NMDs which, in concert with normal physiologic changes during sleep, lead to decreased nocturnal ventilation that often ...

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  Highlights Neuromuscular diseases exhibit a complex array of respiratory physiologic changes that typically progress over time. These physiologic changes can promote significant respiratory abnormalities during sleep, leading to decreased quality of life, significant daytime symptoms, and overall worse survival. ...

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Respiratory Function Loss and Respiratory Endpoints in DMD Duchenne muscular dystrophy (DMD) is the most common and devastating type of muscular dystrophy. Lack of the protein dystrophin causes severe and progressive myofibre degeneration, general muscle weakness and wasting. With increasing ...

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Chronic obstructive pulmonary disease (COPD) imposes a substantial health and economic burden worldwide and is a major cause of death.1 Clinical features of advanced COPD include severe airway obstruction and lung hyperinflation that can lead to chronic respiratory failure, which ...

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Adaptive servo-ventilation (ASV) is a non-invasive ventilatory therapy that provides variable inspiratory positive airway pressure (IPAP) to support inspiration when breathing amplitude is reduced, ensures sufficient respiration when respiratory effort is absent and provides fixed or variable end-expiratory PAP (EPAP) ...

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Obesity is a medical condition in which excess body fat accumulates to the extent that a patient’s health may be adversely affected. Although the prevalence of morbid obesity has remained stable over the past decade, it is still quite ...

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