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Pentraxin-2 is a member of the pentraxin family of proteins, which includes C-reactive protein (CRP), pentraxin-2 and pentraxin-3.1–3 When initially discovered and characterized, pentraxin-2 was known as serum amyloid P (SAP) due to its isolation from amyloid deposits in humans; ...
Paediatric sleep-disordered breathing Sleep-disordered breathing (SDB) is defined as the disruption of normal respiration and ventilation while asleep.1 SDB encompasses multiple sleep disturbances, ranging from mild snoring to obstructive sleep apnoea (OSA).1,2 OSA is characterized by episodic partial or complete ...
Chronic cough, defined as a cough lasting over 8 weeks, has an estimated global prevalence of 10% and has significant detrimental physical, social and psychological consequences on individuals.1,2Â Chronic cough is a complex heterogeneous disease, in which many causative factors need to ...
Lung cancer remains the leading cause of cancer-related death.1Â However, five-year survival in lung cancer varies greatly based on the stage of the disease at diagnosis.2Â Early lung cancer diagnosis through screening with low-dose computed tomography (CT) demonstrated a 20% reduction ...
Paediatric sleep-disordered breathing (SDB) refers to a spectrum of respiratory disorders with intermittent upper-airway obstruction and sleep disruption in children.1 SDB spans primary snoring, upper-airway resistance syndrome, obstructive hypoventilation and obstructive sleep apnoea (OSA), listed in order of increasing severity ...
Coronavirus is a family of enveloped RNA viruses that include the original SARS coronavirus (SARS-CoV) and the recently emerged SARS-CoV-2. According to the World Health Organization, there have been over 500 million confirmed SARS-CoV-2 infections, and well over 6 million deaths from ...
Proton pump inhibitors (PPIs) are a class of antacid drugs that are available by prescription and over-the-counter to treat gastro-oesophageal reflux disease in patients with a number of comorbidities, including chronic respiratory diseases, such as asthma, pulmonary arterial hypertension, chronic ...
The COVID-19 pandemic has infected more than 61 million people and led to more than 1 million deaths worldwide.1Â The USA was one of the later countries to experience large scale community transmission; to date, there have been 13.2 million cases and approaching 300,000 ...
COVID-19 has become one of the greatest challenges in medical history, and the rapid development and approval of effective and safe treatments is essential to minimise the loss of lives during the pandemic. Given the urgency of finding effective strategies, ...
Respiratory syncytial virus (RSV) is an RNA virus that causes lung and respiratory tract infections. It is a leading cause of morbidity and mortality, and is the second largest cause of death in children under 1 year of age. In 2017, it ...
Life-threatening pulmonary illness is one of the most important reasons for admission to an intensive care unit (ICU). Such illnesses frequently require the use of tracheal intubation, deep sedation and mechanical ventilation. Although mechanical ventilation may keep a patient alive (...
Lung diseases are highly prevalent and their early diagnosis is essential for successful treatment. Noninvasive imaging techniques are an important component of the diagnostic process for lung diseases and can also provide important information in terms of prognosis, as well ...
Aerosol administration of drug therapies is a well-established and increasingly important delivery method for patients with acute or chronic respiratory conditions, especially for those receiving critical care. Aerosol therapies are now given to one-quarter of critically ill patients and one-fifth ...
Epidemiology Strains of Mycobacterium tuberculosis (M. tbc) are able, like other bacteria, to develop resistance against antibiotics. The first observations were published shortly after the introduction of streptomycin and were the basis of the current recommendation of combining several antibiotics ...
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