Luigi Montemurro, of Brigham and Women’s Hospital in Boston, met us at ERS 2019 in Madrid to discuss the recent trial of the fixed dose combination of atomoxetine and oxybutynin as the first successful pharmacotherapy for obstructive sleep apnoea.
1. Why is there not yet an effective pharmacotherapy for obstructive sleep apnoea (OSA)? (0:05)
2. What is the mechanism of action of the fixed dose combination of atomoxetine and oxybutynin (ato-oxy) in OSA? (1:16)
3. Could you tell us a little about the recent clinical trial of ato-oxy and its findings? (2:17)
4. What is the safety profile of this combination? (3:41)
5. What were the limitations of the study and what future studies are planned? (5:50)
Speaker disclosures: Luigi Taranto Montemurro is a consultant for Apnimed, Inc.
touchRESPIRATORY.com is an independent information resource supporting physicians, clinicians and leading industry professionals in continuously developing their knowledge, effectiveness and productivity, via free-to-access content in multimedia formats.
Filmed at the European Respiratory Society (ERS) International Congress 2019, Madrid, Spain.
Share this Video
Related Videos In Sleep Related Breathing Disorders
Jan Hedner, ERS 2021: Sulthiame for Moderate to Severe Obstructive Sleep Apnoea
We were delighted to talk with Professor Jan Hedner (The University of Gothenburg, Gothenburg, Sweden) around the rationale, and safety and efficacy findings of using sulthiame in moderate to severe obstructive sleep apnoea. The abstract ‘Safety and efficacy of sulthiame in moderate to severe obstructive sleep apnea: a randomized placebo-controlled parallel-group trial’ (Presentation ID 4383) […]
Terri Weaver, CHEST 2020 – Solriamfetol in Obstructive Sleep Apnea
Following her related presentation at CHEST 2020, Terri Weaver (University of Illinois Chicago, Chicago, IL, USA) took the time to speak with us about the long term effects of solriamfetol on excessive daytime sleepiness and functional outcomes in participants with obstructive sleep apnea. Questions 1. What is known about the long and short term efficacy […]
Margaret Pisani, CHEST 2020 – Sleep and Circadian Rhythm
We caught up with our Editorial Board member Margaret Pisani (Yale University School of Medicine, New Haven, CT, USA) to talk about her presentation at CHEST 2020 Virtual around sleep and circadian rhythm. Questions 1. What are the alterations to sleep and circadian rhythm that are seen in the ICU? Do these affect outcomes? (0:07) […]
Journal articles and more to your inbox
Get the latest clinical insights from touchRESPIRATORYSign me up!