Novel Approaches for Chronic Obstructive Pulmonary Disease, Emphysema and Airways Diseases
Chronic obstructive pulmonary disease (COPD) is the third highest cause of death in the world and presents a considerable health challenge.1 Although several treatments exist to improve the symptoms of COPD, there is currently no way to slow disease progression or to cure it.2 The main obstacle to a cure is the heterogeneous nature of COPD, which incorporates inflammation of the small airways (bronchitis) and destruction of the alveoli (emphysema). A number of effective therapies are available but all are designed to relieve symptoms, and none prevent progression of the disease.2 Disease exacerbation and progression rates vary substantially among patients. Therefore, current research is focussing on more tailored approaches to therapy.
The number of drug therapies for COPD patients has increased in recent years, largely as a result of the modification of older compounds to give greater potency, longer duration of action and improved delivery devices. In addition, many are available in double and even triple combinations that simplify administration.3 Two recent studies have shown that once-daily single-inhaler triple therapies combining fluticasone furoate (an inhaled glucocorticoid), umeclidinium (a long-acting muscarinic antagonist [LAMA]), and vilanterol (a long-acting β2-agonist [LABA]) improved lung function and health-related quality of life (HRQoL), as well as resulting in a significantly lower rate of moderate or severe COPD exacerbations compared to dual therapy with fluticasone/LABA or LAMA/LABA.4,5 At present, the use of a triple therapy is recommended only for patients with severe symptoms or frequent exacerbations despite the combination therapy of LABA and LAMA.2 Several inhaler combinations in triple therapy are being investigated. To maximise the benefits of this therapy, there is a need for further research to identify the subgroup of COPD most likely to respond to this treatment.
Eosinophilic airway inflammation occurs in 15–40% of people with COPD subjects,6 and is generally treated with corticosteroids. However, inhaled corticosteroids are associated with a number of adverse effects and current guidelines recommend limiting their use to patients with more severe disease and increased exacerbation risk.2 New therapeutic approaches are, therefore, being evaluated. A number of monoclonal antibodies (mAbs) have been developed that target cytokine/chemokine-mediated inflammation; these include the interleukin (IL)-1β antagonist canakinumab, IL-1R1 antagonist MEDI8986, IL-5 antagonist mepolizumab, IL-5R antagonist benralizumab, IL-8 antagonist ABX-IL8, and TNF-α antagonist infliximab. To date, targeting the IL-5-mediated pathway appears to be most beneficial.7 However, in July 2018, the US Food and Drug Administration (FDA) decided not to recommend mepolizumab for COPD. The treatment has been approved for patients with eosinophilic asthma since 2015 but the panel concluded that the role of eosinophils in COPD is less clear.8 More recently, IL-17A has been identified as a promising potential therapeutic target in COPD.9 Patient selection is likely to be critical for obtaining optimal clinical responses with these anti-inflammatory therapies.
Phosphodiesterase-4 (PDE-4) is an enzyme that is found in lung structural and inflammatory cells, and is a potentially attractive therapeutic target. Several selective PDE-4 inhibitors are being developed for the treatment of COPD, such as roflumilast, cilomilast, arofylline, AWD-12-281 and SCH-351591.10 While roflumilast and cilomilast have shown clinical benefits in terms of lung function and reducing the frequency of exacerbations, they have shown little impact on quality of life (QoL) or symptoms, and have been associated with gastrointestinal adverse effects and weight loss.11 Novel strategies, such as combination therapies or different route of administration are needed to balance the efficacy of these drugs with minimising adverse events.
Deficiency in alpha1-antitrypsin (α1-AT) has been reported in a small subgroup of patients with COPD. α1-AT is a glycoprotein protease inhibitor encoded by the SERPINA1 gene. Intravenous α1-AT therapy has been found to slow the progression of emphysema in patients with severe α1-AT deficiency.12,13 This treatment has not yet received widespread regulatory approval because of the lack of larger randomised, placebo-controlled trials. Alternative strategies are currently being investigated, including the use of induced pluripotent stem cells, as well as non-augmentation strategies to prevent AAT polymerisation inside hepatocytes.14
Given the limitations of current drug therapy, there has been considerable interest in developing regenerative therapies that aim to improve lung function. These include the application of exogenous stem cells or small molecules to stimulate regeneration by endogenous lung stem/progenitor cells.15 Exogenous mesenchymal stem cells (MSCs) have shown promising findings in animal studies but have yet to show clinical benefit in clinical trials.15
Despite using approved COPD medications, a substantial proportion of emphysema patients suffer symptoms of hyperinflation, in which air becomes trapped in the lungs and prevents new air from coming in, causing severe shortness of breath. In June 2018, the FDA approved the Zephyr® Endobronchial Valve System (EBV) for treating severe emphysema patients. This minimally invasive device is implanted into the airways during a bronchoscopic procedure and occludes a diseased part of the lungs, reducing hyperinflation. Approval was based on a randomised controlled trial, in which the Zephyr EBV provides clinically meaningful benefits in lung function, exercise tolerance, dyspnoea, and quality of life over at least 12 months in patients with little to no collateral ventilation in the treated lobe.16
No permanent cure exists for COPD, and smoking cessation remains the most effective intervention to improve patient prognosis.17 While we have highlighted some important recent advances, more research on the basic cellular and molecular mechanisms of COPD is urgently needed to facilitate the development of new treatments for this disease. As the number of therapeutic options increase, phenotyping will become increasingly important to tailor therapy to the individual patient.
References
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