Chronic Cough

Alyn H Morice, ATS 2022: Phase 2 Trial of BLU-5937 for Refractory Chronic Cough

Published Online: May 25th 2022

touchRESPIRATORY were delighted to speak with Prof. Alyn H Morice (Hull York Medical School, University of Hull, Yorkshire, UK) to discuss the phase 2 trial, investigating BLU-5937 a selective P2x3 antagonist for the treatment of refractory chronic cough.

The abstract ‘Responders Analyses in Objective 24H Cough Frequency in Soothe, A Phase 2b Trial of a Selective P2x3 Antagonist in Refractory Chronic Cough.‘ (Abstract number: P511) was presented at ATS 2022, 13-18 May 2022.

Questions

  1. Could you tell us a little about the clinical burden of refractory chronic cough (RCC) and the unmet needs in its treatment? (0:31)
  2. What is BLU-5937 and what is the rationale for its use in the treatment of RCC? (1:45)
  3. What were the aims, design and eligibility criteria of the SOOTHE study? (3:09)
  4. What were the findings of the responder analysis? (3:48)
  5. What factors predicted response to BLU-5937? (4:14)

Disclosures: Alyn H Morice discloses consulting for Bellus and serving on advisory boards for Bellus.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.

Filmed in coverage of the ATS meeting 2022.

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