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Paediatric sleep-disordered breathing Sleep-disordered breathing (SDB) is defined as the disruption of normal respiration and ventilation while asleep.1 SDB encompasses multiple sleep disturbances, ranging from mild snoring to obstructive sleep apnoea (OSA).1,2 OSA is characterized by episodic partial or complete obstruction of the upper airway, with associated desaturations, awakenings or arousals from sleep.3 Common symptoms include snoring, nocturnal […]

Asthma is a heterogeneous disease with notable variation in its clinical course and response to treatment. Despite management with standard-of-care therapies, a proportion of patients remain uncontrolled and at risk of life-threatening exacerbations and disease worsening. Advances in understanding the heterogeneity of asthma have helped to identify patients who will benefit from an understanding of […]

The InPedILD trial was a phase 3, double-blind placebo-controlled trial investigating nintedanib in children and adolescents with fibrosing interstitial lung diseases (ClinicalTrials.gov: NCT04093024). We were delighted to speak to Dr. Robin Deterding (University of Colorado; Children’s Hospital Colorado, Aurora, CO, USA) to discuss the aims, design, eligibility criteria and findings from the phase 3 study. […]

Nintedanib is an inhibitor of tyrosine kinases involved in the progression of pulmonary fibrosis and blocks the signalling pathways involved in fibrotic processes. We were delighted to speak to Dr. Robin Deterding (University of Colorado; Children’s Hospital Colorado, Aurora, CO, USA) around the incidence, prognosis and unmet needs in the treatment of childhood interstitial lung […]

Bronchiectasis is a chronic pulmonary disorder characterized by permanent bronchial dilatation, which in some children may be reversible, and airway inflammation, and by cough and sputum production, as well as recurrent respiratory tract infections.1 Bronchiectasis is associated with poor quality of life for the child/adolescent and their parents, recurrent exacerbations and high cost to healthcare systems.2 […]

Respiratory syncytial virus (RSV) is a ubiquitous virus that causes annual epidemics of infection in young children in all parts of the world. In temperate regions, epidemics are seasonal, and predictable during the winter months. Approximately half of all infants develop their first RSV infection prior to their first birthday. By 24 months of age, […]

We were delighted to speak with Professor Andrew Bush (Imperial Centre for Paediatrics and Child Health, London, UK) around his presentation on ‘Persistent Bacterial Bronchitis & Bronchiectasis in Children‘, which was presented at The IPCRG 10th World Conference, 6-8 May, 2021. Questions Could you give us a brief overview of persistent bacterial bronchitis (PBB) and […]