Articles
A Focus on Alpha-1 Antitrypsin Deficiency
Alpha-1 antitrypsin deficiency (AATD) was first described by Laurell and Eriksson in 1963. They observed the absence of an alpha-1...
A Medicines Management Review of Treprostinil Sodium (Remodulin®) in Pulmonary Arterial Hypertension
Introduction to Pulmonary Arterial Hypertension Pulmonary hypertension (PH) is a haemodynamic and pathophysiological condition defined as an increase...
A Novel Therapeutic Target in Asthma - The A2B Adenosine Receptor
The observation that adenosine-mediated BHR is reduced but persistent in mast-cell-deficient mice supports the existence of a mast-cell-independent...
A woman with cystic fibrosis, severe hypoxaemia, an atrial thrombus and a patent foramen ovale: a case report
Introduction Cystic fibrosis (CF) is an autosomal, recessively inherited disease caused by mutations in the cystic fibrosis transmembrane...
Activated Factor VII Therapy for Diffuse Alveolar Hemorrhage— Managing a Life-threatening Manifestation of Connective Tissue Diseases, Bone Marrow Transplant, and Other Conditions
Diffuse alveolar hemorrhage is a life-threatening condition that occurs when blood extravasates into the alveolar space and interferes with gas...
Acute Respiratory Distress Syndrome Acquired Brain Injury An Under-recognized and Debilitating Condition
Research is limited regarding cognitive outcomes in survivors of ARDS; however, these patients are at risk for delirium (e.g. acute cerebral...
Advances in Antimicrobial Therapy of Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis
Antimicrobial therapy has made an important contribution to increasing the life expectancy of CF patients and is one of the cornerstones of the...
Advances in the Treatment of Obstructive Sleep Apnea–Hypopnea Syndrome
Recent clinical research on obstructive sleep apnea–hypopnea syndrome (OSAHS) has provided very convincing evidence of the serious clinical...
Advantages and Disadvantages of Medical Therapies for Smoking Cessation
Smoking cessation rates are boosted with behavioural therapy, drugs and motivational support provided by a health professional. Three medical...
Advantages and Disadvantages of Using Continuous Positive Airflow Pressure Therapy on Children
Continuous positive airway pressure (CPAP) is a non-invasive ventilation technique used in children and newborns who are breathing...
Adverse Effects of Anti-tuberculosis Chemotherapy
There is also an opposing view that most patients with TB complete their treatment without serious adverse effects.2 In addition, the frequency of...
Age-related Differences in Immune Responses to the Pneumococcus and the Relation to Vaccination Development
As natural colonisers endemic to the human nasopharynx, the Streptococcus pneumoniae bacteria are easily spread between individuals....
Airway Diseases - Influential Developments in the Last Five Years
.text1 { font-family: verdana; font-size: 14px; font-weight: bold; color: 339966; }There have been major...
Airway Inflammation in Asthma Non-invasive Assessment in Clinical Practice
Airway inflammation is probably the most important component of asthma. In spite of that, monitoring of disease activity in asthma often relies on a...
Airway Pressure Release Ventilation in Pediatrics
Theory APRV was first described by Downs and Stock in 1987. This form of ventilation consists of continuous positive airway pressure (CPAP) with...
Allergic Rhinitis and Asthma - Systemic Condition or Local Disease?
Local allergen exposure at one end of the respiratory system induces mucosal inflammation at the other end, and vice versa. Therefore, upper and...
Alpha-1 Antitrypsin Deficiency and the Genetics of Chronic Obstructive Pulmonary Disease
AAT is a circulating protein, synthesized primarily in the liver, with potent antiprotease and anti-inflammatory activities. While more than 100...
Amantadine, oseltamivir and zanamivir for the treatment of influenza
DISEASE/CONDITION(S) Influenza Note: This guidance does not cover the circumstances of a pandemic, impending pandemic or a widespread epidemic of a...
An unusual foreign body as cause of chronic sinusitis: a case report
Introduction The presence of a foreign body in the nose is a relatively uncommon occurrence. Unlike foreign bodies in other parts of the body that...
