Fabio Midulla discusses the prevalence and clinical consequences of infections in hospitalised children with respiratory symptoms.
FILMED AT THE EUROPEAN RESPIRATORY SOCIETY (ERS) INTERNATIONAL CONGRESS, SEPTEMBER 2016
Can you tell us a little about the prevalence and clinical consequences of the human bocavirus in hospitalised children?
00:13 – Human bocavirus is a new virus, is a DNA virus that was recently discovered in animals, especially in dog. And recently it has been demonstrated that it can be a virus that can trigger acute respiratory infection, not only in adults but also in children. There is not really knowledge about the incidents and the epidemiological importance of this virus. And it’s not clear at the moment which is really the role of this virus, because you can find very often the virus together with other…in coinfection with other virus. So it’s not really clear if it’s a pathogen or not.
What other infections are of concern in hospitalised children with respiratory symptoms?
01:02 – It depends of the age. More young is the child and more often they have a virus infection, especially in the first three years of life. In older children, the virus is less important and there are more important bacteria, pneumococcus for instance, and haemophilus, and most of them say that recently with the immunisation for pneumococcus and haemophilus, these bugs are less important.
What are the findings of the study investigating the development of asthma in infants hospitalised for bronchiolitis?
01:37 – This is an important question. We know very well that 50% around of the infants that have bronchiolitis can develop wheezy bronchitis and asthma after. We don’t know yet if is the virus that change the host and make it an asthmatic patient, or if the virus just identify those kids that will wheeze after. So the research hasn’t answered yet this question. What is coming out recently that is important which kind of virus trigger bronchiolitis. There are some studies that are shown that if we have a bronchiolitis from RSV, you are smaller, you have less familiarity for atrophy, and is less important trigger for asthma comparing to bronchiolitis from rhino viruses.
Does bronchiolitis directly trigger asthma?
02:41 – We don’t know this because we know that almost 50% of the kids that has bronchiolitis will develop asthma, but it’s not clear enough is the virus just identified those kids that will develop atopy and asthma.
Could prevention of bronchiolitis prevent asthma?
03:03 – If the person that will develop asthma has a genetic predisposition, he will develop, or she will develop asthma independently from bronchiolitis. If bronchiolitis will change the immunity of the host and make the child more prone to develop asthma, probably prevention is very important.